CalaVida™ · Liposomal
Pura Energy Liposomal Methyl Charge+
Targeted methylation, daily.
A premium liposomal methylation-support formula in a convenient pump. Pura Energy pairs activated riboflavin, B6, folate, and methyl B12 with TMG (a methyl donor) and a phospholipid liposomal delivery — focused daily support for methylation and cellular energy metabolism. 50 mL bottle, 50 servings.*
- Flavor
- Citrus & Cinnamon
- Serving size
- 1 mL (2 pumps) · 50 mL bottle
$45.00
Key Benefits
- ✓ Supports normal methylation pathways and methyl-donor balance*
- ✓ Supports normal energy metabolism and cellular function*
- ✓ A targeted methylation formula — B2, B6, folate, B12 & TMG, not a full B-complex*
- ✓ Designed to pair with NAD+ support protocols as part of a healthy-aging routine*
- ✓ Liposomal phospholipid delivery in a convenient daily pump*
Important
Contains ethanol. Methyl donors and B vitamins can feel activating for some people — start as directed. Consult a healthcare professional before use if pregnant, nursing, taking medication, or sensitive to B vitamins.
The science behind it
Targeted methylation support
Methylation is part of one-carbon metabolism, the network that moves one-carbon units for normal cellular processes. Pura Energy is positioned as targeted support — activated B2, B6, folate, and methyl B12 plus TMG — rather than a broad multivitamin. [1,2]*
One-carbon & homocysteine pathways (B6, Folate, B12)
Vitamin B6, folate (as calcium folinate), and methyl B12 are key nutrients in one-carbon and homocysteine-related metabolism, supporting normal methylation pathways and normal homocysteine metabolism. [3,4,5,6]*
Methyl-donor support (TMG / Betaine)
Trimethylglycine (betaine) acts as a methyl donor in betaine-homocysteine methyltransferase pathways. At 75 mg per serving, the supported claim lane is methyl-donor balance. [7,8]*
Liposomal phospholipid delivery
Highly purified phospholipids support the liposomal liquid format. Liposomes are lipid vesicles widely studied as carriers for bioactive compounds; we describe this as a liposomal delivery format. [9,10]*
Supplement Facts
| Active Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Riboflavin (as Riboflavin-5-Phosphate) | 10 mg | 769% |
| Vitamin B6 (as Pyridoxine HCl) | 1 mg | 59% |
| Folate (as Calcium Folinate) | 850 mcg DFE | 213% |
| Vitamin B12 (as Methylcobalamin) | 500 mcg | 20,833% |
| Trimethylglycine (betaine) | 75 mg | — |
Amounts are preliminary and shown from the formulation sheet; final values and units are pending label verification.
How to use
Take 2 pumps by mouth. Hold in the mouth 30–90 seconds before swallowing, then repeat to your desired dose or as directed by a healthcare professional. Best on an empty stomach, at least 10 minutes before meals. Use within 90 days of opening.
References
- Lyon P, et al. B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease. Nutrients (2020). NIH/PMC.
- Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy — A Review. Nutrients (2016). NIH/PMC.
- NIH Office of Dietary Supplements. Vitamin B6 — Health Professional Fact Sheet.
- NIH Office of Dietary Supplements. Folate — Health Professional Fact Sheet.
- NIH Office of Dietary Supplements. Vitamin B12 — Health Professional Fact Sheet.
- NIH Office of Dietary Supplements. Riboflavin — Health Professional Fact Sheet.
- Arumugam MK, et al. Beneficial Effects of Betaine: A Comprehensive Review. Biology (2021). NIH/PMC.
- McRae MP. Betaine supplementation decreases plasma homocysteine: a meta-analysis. J Chiropr Med (2013). NIH/PMC.
- Nsairat H, et al. Liposomes: structure, composition, types, and clinical applications. Heliyon (2022). NIH/PMC.
- Rudzinska M, et al. Liposomes as Carriers of Bioactive Compounds in Human Nutrition. Foods (2024). NIH/PMC.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.